The hydroxylation at C-17 in the biosynthesis of the diterpenoid aphidicolin

被引：6
|
作者：
Hanson, JR
Hitchcock, PB
Jarvis, AG
机构：
[1] School of Molecular Sciences, University of Sussex, Brighton
来源：
PHYTOCHEMISTRY | 1997年 / 44卷 / 06期
关键词：
Cephalosporium aphidicola; biosynthesis; diterpenoid; aphidicolin; C-17; hydroxylation;
D O I：
10.1016/S0031-9422(96)00713-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hydroxylation at C-17 in aphidicolin biosynthesis is inhibited by a 17-thiol. A metabolite hydroxylated at C-17 and retaining the cyclopropane ring was obtained from 3 alpha,18-dihydroxy-15 beta,16 beta-methanoaphidicolane whilst aphidicolin itself was obtained from 3 alpha,18-dihydroxyaphidicolane when these substrates were incubated with the fungus, Cephalosporium aphidicola. Copyright (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1055 / 1059
页数：5
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