Libraries from libraries: Generation and comparison of screening profiles

被引：22
|
作者：
Houghten, RA
Blondelle, SE
Dooley, CT
Dorner, B
Eichler, J
Ostresh, JM
机构：
[1] Torrey Pines Institute for Molecular Studies, San Diego, CA 92121
来源：
MOLECULAR DIVERSITY | 1996年 / 2卷 / 1-2期
关键词：
combinatorial libraries; opioid receptor binding assay; antimicrobial assay;
D O I：
10.1007/BF01718699
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library ('libraries from libraries'). Specific results were obtained with each of these libraries upon screening in kappa-opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the 'libraries from libraries' concept for the efficient generation of a variety of chemically diverse combinatorial libraries.
引用
收藏
页码：41 / 45
页数：5
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