Genetic linkage analysis in the age of whole-genome sequencing

被引：181
|
作者：
Ott, Jurg [1 ,2 ]
Wang, Jing [1 ]
Leal, Suzanne M. [3 ]
机构：
[1] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
[2] Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
[3] Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA
来源：
NATURE REVIEWS GENETICS | 2015年 / 16卷 / 05期
基金：
美国国家卫生研究院;
关键词：
HAPLOTYPE RELATIVE RISK; FAMILY-BASED DESIGNS; SIB-PAIR TESTS; COMPLEX TRAITS; HUMAN-DISEASE; EFFICIENT COMPUTATION; ASSOCIATION ANALYSIS; HEARING IMPAIRMENT; WIDE ASSOCIATION; COMMON DISEASES;
D O I：
10.1038/nrg3908
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
引用
收藏
页码：275 / 284
页数：10
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