SERUM LEPTIN CHANGES WITH METFORMIN TREATMENT IN POLYCYSTIC OVARIAN SYNDROME: CORRELATION WITH OVULATION, INSULIN AND TESTOSTERONE LEVELS

被引：0
|
作者：
Upadhyaya, Prerna [1 ]
Rehan, H. S. [2 ]
Seth, Vikas [1 ]
机构：
[1] Mahatma Gandhi Med Coll, Dept Pharmacol, Jaipur, Rajasthan, India
[2] Lady Hardinge Med Coll & Hosp, Dept Pharmacol, New Delhi, India
来源：
EXCLI JOURNAL | 2011年 / 10卷
关键词：
PCOS; leptin; ovulation; metformin; insulin; testosterone; BODY-MASS INDEX; OBESE WOMEN; IN-VITRO; RESISTANCE; WEIGHT; SENSITIVITY; RATS; FAT; HYPERINSULINEMIA; ADIPOSITY;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The relationship between leptin, insulin resistance and other hormonal parameters in polycystic ovarian syndrome (PCOS) is controversial. We investigated the effect of metformin on leptin levels in women with PCOS. Thirty women with PCOS received metformin 500 mg thrice a day. After two months of metformin treatment the mean leptin levels reduced significantly (p < 0.001). Ovulation was achieved in 28 patients, who also had a significant reduction in leptin levels (p < 0.001). Leptin showed significant positive correlation with weight (p < 0.05) and testosterone (p < 0.01), but no significant correlation with insulin. It is concluded that metformin reduces leptin resistance in PCOS women which induces ovulation. Leptin shows a significant correlation with testosterone and not with insulin.
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页码：9 / 15
页数：7
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