RETRACTED: TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway (Retracted Article)

被引：4
|
作者：
Cui, Hongquan [1 ]
Zhang, Ling [1 ]
Chen, Bin [1 ]
Zhang, Fengchun [1 ]
Xu, Haiyan [1 ]
Ma, Guixiang [2 ]
Cao, Longnv [1 ]
Wang, Miao [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Oncol Dept, Sch Med, Suzhou Kowloon Hosp, Suzhou 215127, Peoples R China
[2] Siyang Hosp, Oncol Dept, Suqian 223798, Peoples R China
来源：
CONTRAST MEDIA & MOLECULAR IMAGING | 2022年 / 2022卷
关键词：
METASTASIS; EXPRESSION;
D O I：
10.1155/2022/5697034
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6 levels exhibited inferior overall survival. Mechanistically, overexpression of TNFAIP6 raised beta-catenin ectopic nuclear distribution and activated the Wnt/beta-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression.
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页数：9
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