Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc x Pietrain population

被引：13
|
作者：
Grosse-Brinkhaus, Christine [1 ]
Jonas, Elisabeth [1 ,2 ]
Buschbell, Heiko [1 ]
phatsara, Chirawath [1 ,3 ]
Tesfaye, Dawit [1 ]
Juengst, Heinz [1 ]
Looft, Christian [1 ]
Schellander, Karl [1 ]
Tholen, Ernst [1 ]
机构：
[1] Univ Bonn, Inst Anim Sci, Grp Anim Breeding & Genet, D-53115 Bonn, Germany
[2] Univ Sydney, ReproGen Ctr Adv Technol Anim Genet & Reprod, Fac Vet Sci, Sydney, NSW 2006, Australia
[3] Chiang Mai Univ, Dept Anim & Aquat Sci, Fac Agr, Chiang Mai 50000, Thailand
来源：
GENETICS SELECTION EVOLUTION | 2010年 / 42卷
关键词：
CHEMICAL BODY-COMPOSITION; EXPRESSED SEQUENCE TAGS; LARGE WHITE-PIGS; SUS-SCROFA; GENOME SCAN; RESOURCE POPULATION; COMPARATIVE MAP; LANDRACE CROSS; WILD BOAR; LOCI;
D O I：
10.1186/1297-9686-42-39
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Background: Quantitative trait loci (QTL) analyses in pig have revealed numerous individual QTL affecting growth, carcass composition, reproduction and meat quality, indicating a complex genetic architecture. In general, statistical QTL models consider only additive and dominance effects and identification of epistatic effects in livestock is not yet widespread. The aim of this study was to identify and characterize epistatic effects between common and novel QTL regions for carcass composition and meat quality traits in pig. Methods: Five hundred and eighty five F-2 pigs from a Duroc x Pietrain resource population were genotyped using 131 genetic markers (microsatellites and SNP) spread over the 18 pig autosomes. Phenotypic information for 26 carcass composition and meat quality traits was available for all F-2 animals. Linkage analysis was performed in a two-step procedure using a maximum likelihood approach implemented in the QxPak program. Results: A number of interacting QTL was observed for different traits, leading to the identification of a variety of networks among chromosomal regions throughout the porcine genome. We distinguished 17 epistatic QTL pairs for carcass composition and 39 for meat quality traits. These interacting QTL pairs explained up to 8% of the phenotypic variance. Conclusions: Our findings demonstrate the significance of epistasis in pigs. We have revealed evidence for epistatic relationships between different chromosomal regions, confirmed known QTL loci and connected regions reported in other studies. Considering interactions between loci allowed us to identify several novel QTL and trait-specific relationships of loci within and across chromosomes.
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页数：13
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