Effect of neoadjuvant chemotherapy for lymph node micrometastasis and tumor cell microinvolvement in the patients with esophageal carcinoma

被引：10
|
作者：
Natsugoe, S [1 ]
Matsumoto, M [1 ]
Nakashima, S [1 ]
Okumura, H [1 ]
Miyazono, F [1 ]
Kijima, F [1 ]
Ishigami, S [1 ]
Aridome, K [1 ]
Kusano, C [1 ]
Baba, M [1 ]
Takao, S [1 ]
Aikou, T [1 ]
机构：
[1] Kagoshima Univ, Sch Med, Dept Surg 1, Kagoshima 8908520, Japan
来源：
CANCER LETTERS | 2000年 / 159卷 / 02期
关键词：
lymph node metastasis; micrometastasis; tumor cell microinvolvement; cytokeratin; chemotherapy; esophageal cancer;
D O I：
10.1016/S0304-3835(00)00505-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Micrometastasis (MM) and tumor cell microinvolvement (TCM) in the lymph node were immunohistochemically evaluated using the cytokeratin (CK) antibody between a surgery group (n = 20; 929 lymph nodes) and a chemotherapy group (n = 20; 1052 lymph nodes). The incidence of MM +/- TCM in the surgery and chemotherapy groups was 50.0 (10/20) and 55.0% ( 11/20). respectively. Limiting the analysis to TCM alone revealed that the incidence in the chemotherapy group (10.0% 2/20) was significantly lower than that in the surgery group (40.0%: 8/20; P = 0.032). Preoperative chemotherapy in this regime was not effective, except for some patients with TCM alone. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.
引用
收藏
页码：119 / 125
页数：7
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