Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

被引：35
|
作者：
Dubee, Vincent [1 ,2 ,3 ,4 ]
Soroka, Daria [1 ,2 ,3 ]
Cortes, Melanie [1 ,2 ,3 ]
Lefebvre, Anne-Laure [1 ,2 ,3 ]
Gutmann, Laurent [1 ,2 ,3 ,5 ]
Hugonnet, Jean-Emmanuel [1 ,2 ,3 ]
Arthur, Michel [1 ,2 ,3 ]
Mainardi, Jean-Luc [1 ,2 ,3 ,5 ]
机构：
[1] INSERM, LRMA, Ctr Rech Cordeliers, Equipe 12,UMR S 1138, Paris, France
[2] Univ Paris 06, Sorbonne Univ, Ctr Rech Cordeliers, UMR S 1138, Paris, France
[3] Univ Paris 05, Ctr Rech Cordeliers, Sorbonne Paris Cite, UMR S 1138, Paris, France
[4] Hop St Antoine, AP HP, Serv Reanimat Med, F-75571 Paris, France
[5] Hop Europeen Georges Pompidou, AP HP, Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 05期
关键词：
MASSILIENSE; CEPHALOSPORIN; INFECTIONS; ACID;
D O I：
10.1128/AAC.05080-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The production of beta-lactamases BlaMab and BlaC contributes to beta-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from >= 256 to 16 to 64 mu g/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.
引用
收藏
页码：2938 / 2941
页数：4
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