Homeostasis and the age-associated defect of CD4 T cells

被引：85
|
作者：
Swain, S [1 ]
Clise-Dwyer, K [1 ]
Haynes, L [1 ]
机构：
[1] Trudeau Inst, Saranac Lake, NY 12983 USA
来源：
SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 05期
关键词：
CD4 T cells; aging; immunization; homeostasis;
D O I：
10.1016/j.smim.2005.05.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-cellular milieu and together these processes ensure that a population of naive CD4 T cells persists into old age. However, the naive CD4 T cells from aged animals show reduced IL-2 production, proliferation, helper function and effector generation and memory function. We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：370 / 377
页数：8
相关论文
共 50 条
  • [1] Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
    Tsukamoto, Hirotake
    Clise-Dwyer, Karen
    Huston, Gail E.
    Duso, Debra K.
    Buck, Amanda L.
    Johnson, Lawrence L.
    Haynes, Laura
    Swain, Susan L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (43) : 18333 - 18338
  • [2] Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells
    Garcia, GG
    Berger, SB
    Akha, AAS
    Miller, RA
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (02) : 622 - 631
  • [3] Age-associated changes within CD4+ T cells
    Kovaiou, Rania D.
    Grubeck-Loebenstein, Beatrix
    [J]. IMMUNOLOGY LETTERS, 2006, 107 (01) : 8 - 14
  • [4] Age-associated skewing of murine T cell repertoires in CD4(+) and CD8(+) T lymphocyte subsets.
    Koker, MM
    Mosley, RL
    Miller, RA
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1997, 45 (09) : P208 - P208
  • [5] Age-associated changes in the factors regulating homeostasis of mature T cells
    Bondi-Boyd, B
    Leroy, E
    Kieper, WC
    Tan, JT
    Surh, CD
    [J]. FASEB JOURNAL, 2002, 16 (04): : A345 - A345
  • [6] Telomerase deficiency reflects age-associated changes in CD4+ T cells
    Diana M. Matthe
    Oana-Maria Thoma
    Tobias Sperka
    Markus F. Neurath
    Maximilian J. Waldner
    [J]. Immunity & Ageing, 19
  • [7] Telomerase deficiency reflects age-associated changes in CD4+T cells
    Matthe, Diana M.
    Thoma, Oana-Maria
    Sperka, Tobias
    Neurath, Markus F.
    Waldner, Maximilian J.
    [J]. IMMUNITY & AGEING, 2022, 19 (01)
  • [8] The role of CD4 in regulating homeostasis of T helper cells
    Rolf König
    Xiaoli Shen
    Rosario Maroto
    Timothy L. Denning
    [J]. Immunologic Research, 2002, 25 : 115 - 130
  • [9] The role of CD4 in regulating homeostasis of T helper cells
    König, R
    Shen, XL
    Maroto, R
    Denning, TL
    [J]. IMMUNOLOGIC RESEARCH, 2002, 25 (02) : 115 - 130
  • [10] Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects
    Tsukamoto, Hirotake
    Huston, Gail E.
    Dibble, John
    Duso, Debra K.
    Swain, Susan L.
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (08): : 4535 - 4544
12345