Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

被引：34
|
作者：
Martinon, Fabio [1 ]
机构：
[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland
来源：
IMMUNITY | 2012年 / 36卷 / 03期
关键词：
D O I：
10.1016/j.immuni.2012.03.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Danger signals released by damaged organelles can promote inflammation. In this issue of Immunity, Shimada et al. (2012) report that oxidized DNA, released by mitochondria, directly binds and activates the NLRP3 inflammasome.
引用
收藏
页码：313 / 315
页数：3
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