Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium

被引:17
|
作者
Hart, Phil A. [1 ]
Papachristou, Georgios, I [1 ]
Park, Walter G. [2 ]
Dyer, Anne-Marie [3 ]
Chinchilli, Vernon M. [3 ]
Afghani, Elham [4 ]
Akshintala, Venkata S. [4 ]
Andersen, Dana K. [5 ]
Buxbaum, James L. [6 ]
Conwell, Darwin L. [1 ,26 ]
Dungan, Kathleen M. [7 ]
Easler, Jeffrey J. [8 ]
Fogel, Evan L. [8 ]
Greenbaum, Carla J. [9 ]
Kalyani, Rita R. [10 ]
Korc, Murray [11 ]
Kozarek, Richard [9 ,12 ]
Laughlin, Maren R. [13 ]
Lee, Peter J. [1 ]
Maranki, Jennifer L. [14 ]
Pandol, Stephen J. [15 ]
Phillips, Anna Evans [16 ]
Serrano, Jose [5 ]
Singh, Vikesh K. [4 ]
Speake, Cate [9 ]
Tirkes, Temel [17 ]
Toledo, Frederico G. S. [18 ]
Trikudanathan, Guru [19 ]
Vege, Santhi Swaroop [20 ]
Wang, Ming [3 ]
Yazici, Cemal [21 ]
Zaheer, Atif [22 ]
Forsmark, Christopher E. [23 ]
Bellin, Melena D. [24 ,25 ]
Yadav, Dhiraj [16 ]
机构
[1] Ohio State Univ, Wexner Med Ctr, Div Gastroenterol Hepatol & Nutr, Columbus, OH 43210 USA
[2] Stanford Univ, Sch Med, Div Gastroenterol, Palo Alto, CA 94304 USA
[3] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA
[4] Johns Hopkins Med Inst, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA
[5] Natl Inst Diabet & Digest & Kidney Dis NIDDK, Div Digest Dis & Nutr, NIH, Bethesda, MD USA
[6] Univ Southern Calif, Keck Sch Med, Div Gastroenterol, Los Angeles, CA 90007 USA
[7] Ohio State Univ, Wexner Med Ctr, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA
[8] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
[9] Benaroya Res Inst Virginia Mason, Ctr Intervent Immunol, Seattle, WA USA
[10] Johns Hopkins Med Inst, Div Endocrinol Diabet & Metab, Baltimore, MD 21205 USA
[11] Univ Calif Irvine, Div Endocrinol, Irvine, CA USA
[12] Virginia Mason Franciscan Hlth, Ctr Digest Hlth, Seattle, WA USA
[13] Natl Inst Diabet & Digest & Kidney Dis NIDDK, Div Diabet Endocrinol & Metab Dis, NIH, Bethesda, MD USA
[14] Penn State Milton Hershey Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Hershey, PA USA
[15] Cedars Sinai Med Ctr, Div Digest & Liver Dis, Los Angeles, CA 90048 USA
[16] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA
[17] Indiana Univ, Dept Radiol & Imaging Serv, Indianapolis, IN 46204 USA
[18] Univ Pittsburgh, Med Ctr, Dept Med, Div Endocrinol & Metab, Pittsburgh, PA USA
[19] Univ Minnesota, Div Gastroenterol, Minneapolis, MN USA
[20] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
[21] Univ Illinois, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL USA
[22] Johns Hopkins Med Inst, Russell H Morgan Dept Radiol, Baltimore, MD 21205 USA
[23] Univ Florida, Div Gastroenterol Hepatol & Nutr, Gainesville, FL USA
[24] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA
[25] Univ Minnesota, Sch Med, Dept Surg, Minneapolis, MN 55455 USA
[26] Univ Kentucky, Coll Med, Dept Internal Med, Lexington, KY USA
关键词
pancreatogenic diabetes; type 3c diabetes; beta cell; insulin; autoantibody; epidemiology; AP; acute pancreatitis; CP; chronic pancreatitis; DCC; data coordinating center; DM; diabetes mellitus; DREAM; Diabetes RElated to Acute pancreatitis and its Mechanisms; FSIGTT; frequently sampled intravenous glucose tolerance testing; OGTT; oral glucose tolerance testing; MMTT; mixed meal tolerance testing; T1DAPC; Type 1 Diabetes in Acute Pancreatitis Consortium; METHODOLOGY;
D O I
10.1097/MPA.0000000000002079
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.
引用
收藏
页码:568 / 574
页数:7
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