New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology

被引：28

作者：

Brandes, Alba A. ^{[1
]}

Bartlotti, Marco ^{[1
]}

Marucci, Gianluca ^{[2
]}

Ghimenton, Claudio ^{[3
]}

Agati, Raffaele ^{[4
]}

Fioravanti, Antonio ^{[5
]}

Mascarin, Maurizio ^{[6
]}

Volpin, Lorenzo ^{[7
]}

Ammannati, Franco ^{[8
]}

Masotto, Barbara ^{[9
]}

Gardiman, Marina Paola ^{[10
]}

De Biase, Dario ^{[11
]}

Tallini, Giovanni ^{[11
]}

Crisi, Girolamo ^{[12
]}

Bartolini, Stefania

Franceschi, Enrico ^{[1
]}

机构：

[1] Bellaria Maggiore Hosp, Azienda USL IRCCS Inst Neurol Sci, Dept Med Oncol, I-40139 Bologna, Italy

[2] Univ Bologna, Sect Pathol, M Malpighi Bellaria Hosp, Dept Biomed & NeuroMotor Sci DiBiNeM, Bologna, Italy

[3] Verona Hosp, Dept Pathol, Verona, Italy

[4] Bellaria Maggiore Hosp, Azienda USL IRCCS Inst Neurol Sci, Dept Neuroradiol, Bologna, Italy

[5] Bellaria Hosp, IRCCS Inst Neurol Sci, Dept Neurosurg, Azienda USL, Bologna, Italy

[6] CRO, Dept Radiotherapy Unit, Aviano, Italy

[7] San Bortolo Hosp, Dept Neurosci & Neurosurg, Vicenza, Italy

[8] Careggi Univ Hosp, Dept Neurosurg 1, Florence, Italy

[9] Univ Verona, Dept Neurosci, Neurosurg Sect, I-37100 Verona, Italy

[10] Univ Hosp, Dept Med DIMED, Surg Pathol & Cytopathol Unit, Padua, Italy

[11] Univ Bologna, Bellaria Hosp, Anat Pathol Unit, Dept Med DIMES, Bologna, Italy

[12] Parma Univ Hosp, Dept Neuroradiol, Parma, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2015年 / 94卷 / 03期

关键词：

Medulloblastoma; Adults; Treatment; SHH; WNT; HIGH-DOSE CHEMOTHERAPY; STEM-CELL RESCUE; CRANIOSPINAL RADIATION-THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; HIGH-RISK MEDULLOBLASTOMA; NONMETASTATIC MEDULLOBLASTOMA; ADJUVANT CHEMOTHERAPY; PROGNOSTIC-FACTORS; BRAIN; RECURRENT;

D O I：

10.1016/j.critrevonc.2014.12.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloblastoma is the most common central nervous system tumor in children, while it is extremely rare in adults. Multimodal treatment involving surgery, radiotherapy and chemotherapy can improve the prognosis of this disease, and recent advances in molecular biology have allowed the identification of molecular subgroups (WNT, SHH, Groups 3 and 4), each of which have different cytogenetic, mutational and gene expression signatures, demographics, histology and prognosis. The present review focuses on the state of the art for adult medulloblastoma treatment and on novel molecular advances and their future implications in the treatment of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：348 / 359

页数：12

共 50 条

[1] Oncology Scan-Molecular Genotyping of Medulloblastoma: A New Treatment Era
Terezakis, Stephanie A.
Gibbs, Iris C.
Haas-Kogan, Daphne A.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 89 (02): : 229 - 231
[2] Medulloblastoma in the Molecular Era
Kuzan-Fischer, Claudia Miranda
Juraschka, Kyle
Taylor, Michael D.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, 2018, 61 (03) : 292 - 301
[3] Current therapy and new perspectives in the treatment of medulloblastoma
Whelan, HT
Krouwer, HG
Schmidt, MH
Reichert, KW
Kovnar, EH
PEDIATRIC NEUROLOGY, 1998, 18 (02) : 103 - 115
[4] New Molecular Targets for the Treatment of Medulloblastoma
Ramey, Wyatt
Kalani, M. Yashar S.
WORLD NEUROSURGERY, 2013, 80 (1-2) : 6 - 7
[5] Medulloblastoma: "Onset of the molecular era"
Dhanyamraju, Pavan Kumar
Patel, Trupti N.
Dovat, Sinisa
MOLECULAR BIOLOGY REPORTS, 2020, 47 (12) : 9931 - 9937
[6] Medulloblastoma: “Onset of the molecular era”
Pavan Kumar Dhanyamraju
Trupti N. Patel
Sinisa Dovat
Molecular Biology Reports, 2020, 47 : 9931 - 9937
[7] SURVEY OF CANADIAN NEURO-ONCOLOGY CLINICIANS ABOUT THE TREATMENT OF ADULT MEDULLOBLASTOMA
Climans, Seth
Cacciotti, Chantel
Lim-Fat, Mary Jane
NEURO-ONCOLOGY, 2022, 24 : 236 - 236
[8] Review of the molecular genetics and chemotherapeutic treatment of adult and paediatric medulloblastoma
Newton, HB
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (12) : 2089 - 2104
[9] Medulloblastoma genomics in the modern molecular era
Kumar, Rahul
Liu, Anthony P. Y.
Northcott, Paul A.
BRAIN PATHOLOGY, 2020, 30 (03) : 679 - 690
[10] IMAGING OF METASTATIC MEDULLOBLASTOMA IN THE MOLECULAR ERA
Zapotocky, Michal
Lassaletta, Alvaro
Bouffet, Eric
Bartels, Ute
Huang, Annie
Laughlin, Suzanne
Tabori, Uri
Taylor, Michael
Hawkins, Cynthia
Raybaud, Charles
Ramaswamy, Vijay
NEURO-ONCOLOGY, 2016, 18 : 110 - 110

← 1 2 3 4 5 →