Efficient cleavage of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H2SO4 in CH2Cl2

被引：31
|
作者：
Strazzolini, P [1 ]
Misuri, N [1 ]
Polese, P [1 ]
机构：
[1] Univ Udine, Dept Chem Sci & Technol, I-33100 Udine, Italy
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 12期
关键词：
sulfuric acid; dichloromethane; deprotection; tert-butyl ester; N-Boc-amine;
D O I：
10.1016/j.tetlet.2005.01.129
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new procedure for the deprotection of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H2SO4 in CH2Cl2 is described. The proposed method is simple, cheap, eco-friendly and represents a valid alternative to existing ones, with special significance in large scale applications. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2075 / 2078
页数：4
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