Magnetic response of mitochondria-targeted cancer cells with bacterial magnetic nanoparticles

被引：19

作者：

Choi, Jungin ^{[2
]}

Shin, Jaeha ^{[3
]}

Lee, Junghoon ^{[1
,2
,3
]}

Cha, Misun ^{[1
]}

机构：

[1] Seoul Natl Univ, Interuniv Semicond Res Ctr, Seoul 151744, South Korea

[2] Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 151742, South Korea

[3] Seoul Natl Univ, Div WCU Multiscale Mech Design, Sch Mech & Aerosp Engn, Seoul 151744, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 60期

基金：

新加坡国家研究基金会;

关键词：

CYTOCHROME-C; PROTEIN; DEATH; IMMUNOASSAY; ANTIOXIDANT; DELIVERY; NECROSIS; PATHWAY;

D O I：

10.1039/c2cc33659f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We first demonstrate the effects of magnetic trapping of mitochondria using aptamer conjugated to bacterial magnetic nanoparticles that allowed targeting of the mitochondrial cytochrome c in the treatment of cancer cells. Our findings offer a new approach for targeted cell therapy, with the advantage of remote control over subcellular elements.

引用

页码：7474 / 7476

页数：3

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