Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

被引：917
|
作者：
Chen, Qian [1 ]
Feng, Liangzhu [1 ]
Liu, Jingjing [1 ]
Zhu, Wenwen [1 ]
Dong, Ziliang [1 ]
Wu, Yifan [1 ]
Liu, Zhuang [1 ]
机构：
[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 33期
基金：
中国国家自然科学基金;
关键词：
GUIDED PHOTOTHERMAL THERAPY; CANCER-THERAPY; PHOTODYNAMIC THERAPY; PROTEIN CAPSULES; DRUG-DELIVERY; SOLID TUMORS; IN-VIVO; PENETRATION; OXYGEN; CELLS;
D O I：
10.1002/adma.201601902
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.
引用
收藏
页码：7129 / +
页数：9
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