No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes

被引：34
|
作者：
Marino, C
Giorda, R
Vanzin, L
Molteni, M
Lorusso, ML
Nobile, M
Baschirotto, C
Alda, M
Battaglia, M
机构：
[1] Sci Inst Eugenio Medea, Dept Child Psychiat, I-23842 Bosisio Parini, LC, Italy
[2] Mol Biol Lab, I-23842 Bosisio Parini, LC, Italy
来源：
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | 2003年 / 12卷 / 04期
关键词：
dyslexia; genetics; TDT; dopamine receptors;
D O I：
10.1007/s00787-003-0332-4
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD. No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.
引用
收藏
页码：198 / 202
页数：5
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