Glycosylation of 2-thiohydantoin derivatives. Synthesis of some novel S-alkylated and S-glucosylated hydantoins

被引：43
|
作者：
Khodair, AI [1 ]
机构：
[1] Tanta Univ, Fac Educ, Dept Chem, Kafr El Sheikh Branch, Kafr El Sheikh, Egypt
来源：
CARBOHYDRATE RESEARCH | 2001年 / 331卷 / 04期
关键词：
3-aryl-2-thiohydantoins; 3-aryl-5-((Z)-arylidene)-2-(2-methylthioethyl)-2-thiohydantoins; 3-aryl-5-((Z)-arylidene)-2-(2; 3; 4; 6; '-tetra-; O-acetyl-beta-D-glucopyranosyl)-2-thiohydantoins; antiviral; antitumor agents;
D O I：
10.1016/S0008-6215(01)00040-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
3-Aryl-5-((Z)-arylidene)-3-aryl-2-(2-methylthioethyl)-2-thiohydantoins 3a-f and 3-aryl-5-((Z)-arylidene)-2- (2',3',4',6'-tetra-O-acetyl-beta -D-glucopyranosyl)-2-thiohydantoins 7a-n were prepared from the reaction of 3-aryl-5-((Z)-arylidene)-2-thiohydantoins 2a-n with methylthioethyl chloride or 2',3',4',6'-tetra-O-acetyl-alpha -D-glucopyranosyl bromide via three different routes. The compounds did not display any antiviral and antitumoral activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：445 / 453
页数：9
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