Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B-abortus

被引：0
|
作者：
Oñate, AA
Vemulapalli, R
Andrews, E
Schurig, GG
Boyle, S
Folch, H
机构：
[1] Univ Concepcion, Fac Biol Sci, Dept Microbiol, Concepcion, Chile
[2] Univ Austral Chile, Fac Med, Dept Immunol, Valdivia, Chile
[3] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Ctr Mol Med & Infect Dis, Blacksburg, VA 24061 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccination of mice with Escherichia coli expressing Brucella Cu/Zn superoxide dismutase (SOD) [E. coli (pBSSOD)] induced a significant level of protection against virulent Brucella abortus challenge, although this level was not as high as the one reached with B. abortus vaccine strain RB51. In addition, vaccination with E. coli(pBSSOD)) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a thioredoxin-Cu/Zn SOD fusion protein.
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页码：986 / 988
页数：3
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