SERS as an analytical tool in environmental science: The detection of sulfamethoxazole in the nanomolar range by applying a microfluidic cartridge setup

被引：70

作者：

Patze, Sophie ^{[1
,2
]}

Huebner, Uwe ^{[1
]}

Liebold, Falk ^{[3
,4
]}

Weber, Karina ^{[1
,2
]}

Cialla-May, Dana ^{[1
,2
]}

Popp, Juergen ^{[1
,2
]}

机构：

[1] Leibniz Inst Photon Technol, Albert Einstein Str 9, D-07745 Jena, Germany

[2] Friedrich Schiller Univ Jena, Inst Phys Chem & Abbe Ctr Photon, Helmholtzweg 4, D-07743 Jena, Germany

[3] Analyt Jena AG, Konrad Zuse Str 1, D-07745 Jena, Germany

[4] Microepsilon Grp, Heinrich Hertz Str 8, D-07629 Hermsdorf, Germany

来源：

ANALYTICA CHIMICA ACTA | 2017年 / 949卷

关键词：

Surface enhanced Raman spectroscopy; Microfluidics; Sulfamethoxazole detection; Environmental safety; Molecular orientation; SURFACE-ENHANCED RAMAN; NAIROBI RIVER-BASIN; PLASMONIC ARRAYS; SILVER COLLOIDS; MONOSUBSTITUTED BENZENES; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; SPECTROSCOPY; PHARMACEUTICALS; ANTIBIOTICS;

D O I：

10.1016/j.aca.2016.10.009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Sulfamethoxazole (SMX) is a commonly applied antibiotic for treating urinary tract infections; however, allergic reactions and skin eczema are known side effects that are observed for all sulfonamides. Today, this molecule is present in drinking and surface water sources. The allowed concentration in tap water is 2.10(-7) mol L-1. SMX could unintentionally be ingested by healthy people when drinking contaminated tap water, representing unnecessary drug intake. To assess the quality of tap water, fast, specific and sensitive detection methods are required, in which consequence measures for improving the purification of water might be initiated in the short term. Herein, the quantitative detection of SMX down to environmentally and physiologically relevant concentrations in the nanomolar range by employing surface-enhanced Raman spectroscopy (SERS) and a microfluidic cartridge system is presented. By applying surface-water samples as matrices, the detection of SMX down to 2.2.10(-9) mol L-1 is achieved, which illustrates the great potential of our proposed method in environmental science. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7