A pilot study on association between phthalate exposure and missed miscarriage

被引:0
|
作者
Yi, H. [1 ,5 ]
Gu, H. [1 ]
Zhou, T. [2 ,6 ]
Chen, Y. [1 ]
Wang, G. [3 ]
Jin, Y. [3 ]
Yuan, W. [4 ]
Zhao, H. [1 ]
Zhang, L. [1 ]
机构
[1] Fudan Univ, Peoples Hosp Shanghai 5, Dept Obstet & Gynecol, Shanghai, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Qingpu Branch, Shanghai, Peoples R China
[3] Shanghai Municipal Ctr Dis Control & Prevent, Lab Hygien Inspect, Shanghai, Peoples R China
[4] Shanghai Inst Planned Parenthood Res, Natl Populat & Family Planning Key Lab Contracept, Dept Reprod Epidemiol & Social Sci, Shanghai, Peoples R China
[5] Matern & Child Care Ctr Fujian Prov, Dept Obstet & Gynecol, Shanghai, Peoples R China
[6] Shanghai Precis Diagnost Co Ltd, Div Biomarker Dev, Shanghai, Peoples R China
关键词
Phthalate; Missed miscarriage; DEHP; DMP; Sex hormone; ACID ESTERS; PREGNANCY; PROGESTERONE; ESTRADIOL; DIAGNOSIS; ABORTION; WOMEN;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVE: The incidence of missed miscarriage has been increasing during the past decade in China and the etiology of about half of the cases remains unclear. Exposure to phthalates has been considered as a risk factor. The aim of this paper is to assess the association between exposure to phthalates and missed miscarriage. PATIENTS AND METHODS: A case-control study was performed including 150 cases of missed miscarriage and 150 matched controls with normal pregnancies. The levels of phthalate exposure were compared between the two groups by measuring 13 phthalate metabolites in urine samples. Blood samples were collected for serum hormone measurement to assess the relationship between serum hormone level and phthalate exposure. RESULTS: The urinary levels of metabolites of di-(2-ethylhexyl)phthalate (DEHP) and dimethyl phthalate (DMP) were significantly higher in the cases than in the controls. A strong dose-response relationship was observed between urinary metabolite levels and the odds of missed miscarriage. Monomethyl phthalate (MMP), a metabolite of DMP, and mono-2-ethylhexyl phthalate (MEHP), a metabolite of DEHP, each had significant negative correlation with maternal serum hormone levels. CONCLUSIONS: In the current study, exposure to DEHP and DMP was found to be associated with missed miscarriage. Interruption of hormone synthesis by DMP and DEHP metabolites represents a plausible mechanism of phthalate reproductive toxicity.
引用
收藏
页码:1894 / 1902
页数:9
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