Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa

被引：94
|
作者：
Aubert, D
Poirel, L
Chevalier, J
Leotard, S
Pages, JM
Nordmann, P
机构：
[1] Assistance Publ Hop Paris, Hop Bicetre, Fac Med, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France
[2] Fac Med Marseille, INSERM, CJF96 06, F-13385 Marseille, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期
关键词：
D O I：
10.1128/AAC.45.6.1615-1620.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pseudomonas aeruginosa clinical isolate SOF-1 was resistant to cefepime and susceptible to ceftazidime. This resistance phenotype was explained by the expression of OXA-31, which shared 98% amino acid identity with a class D beta -lactamase, OXA-1. The oxa-31 gene was located on a ca. 300-kb nonconjugative plasmid and on a class 1 integron, No additional efflux mechanism for cefepime was detected in P. aeruginosa SOF-1, Resistance to cefepime and susceptibility to ceftazidime in P. aeruginosa were conferred by OXA-1 as well.
引用
收藏
页码：1615 / 1620
页数：6
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