Regulating B-cell activation and survival in response to TLR signals

被引：67

作者：

Gerondakis, Steve ^{[1
]}

Grumont, Raelene J. ^{[1
]}

Banerjee, Ashish ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 06期

关键词：

TLR4; signaling; NF-kappa B; ERK; cell cycle; apoptosis;

D O I：

10.1038/sj.icb.7100097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor kappa B pathway controls and coordinates B-cell division and survival following TLR4 engagement.

引用

页码：471 / 475

页数：5

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