INDEPENDENT PREDICTORS OF ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH ACUTE CORONARY SYNDROME AFTER PERCUTANEOUS CORONARY INTERVENTION DURING HOSPITALIZATION

Purpose: to elucidate independent clinical and laboratory predictors of adverse cardiovascular events (ACVE) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) with stenting in early inhospital period. Materials and methods. We included in this prospective single center study 130 patients with ACS who underwent PCI with stenting. All patients prior to and after PCI received dual antiplatelet therapy with acetylsalicylic acid and clopidogrel. In 12-48 hours after PCI we measured residual platelet reactivity (RPR) using light aggregometry. In 57 patients simultaneously we performed genotyping of cyp2c19*2 polymorphisms. The following ACVE were used as end-points and were registered during inhospital observation (mean duration 9.7 +/- 3.2 days): sudden death, stent thrombosis, arterial thrombosis of other localization, recurrent angina, cardiac rhythm disturbances requiring special therapy. Results. Repetitive ACVE were observed in 32 patients. According to unifactorial regression analysis risk factors of their development were, ADP F-induced RPR (p<0.001), levels of creatinine (p<0.001), hemoglobin (p<0.001), and glucose (p=0.026), age (p=0.01), iron-deficiency anemia (p=0.01), left ventricular ejection fraction (p=0.004), number of stents (p=0.01s). According to results of multifactorial regression analysis independent predictors of ACVE were: ADP-induced RPR >76% (p=0.003), levels of creatinine >189 mu mol/L (p=0.003), and hemoglobin <114 g/L (p=0.004). Significant effect of homozygous carriage of CYP2C19*2 (G681A) (A/A) on development of stent thrombosis was also detected (p=0.028). Conclusion. ADP-induced RPR, levels of creatinine and hemoglobin were found to be independent predictors of inhospital ACVE after myocardial revascularization with stenting in patients with ACS.