Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases

被引：90
|
作者：
Klinger, G
Morad, Y
Westall, CA
Laskin, C
Spitzer, KA
Koren, G
Ito, S [1 ]
Buncic, RJ
机构：
[1] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Clin Pharmacol & Toxicol,Motherisk Programme, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Hosp Sick Children, Dept Ophthalmol, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Dept Med, Toronto, ON, Canada
[4] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON, Canada
来源：
LANCET | 2001年 / 358卷 / 9284期
关键词：
D O I：
10.1016/S0140-6736(01)06004-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic use of chloroquine and hydroxychloroquine in the treatment of rheumatic disease carries a small risk of sight-threatening pigmentary retinopathy. To obtain safety data for Its use In pregnancy, we did ophthalmic examinations In 21 children born to women who took these drugs during pregnancy. Average daily maternal doses of the two drugs were 317 mg hydroxychloroquine and 332 mg chloroquine. The mean duration of gestational exposure was 7.2 months. No ophthalmic abnormality was detected In these children. Therapeutic use of these drugs during pregnancy may not pose a significant risk of ocular toxicity to offspring.
引用
收藏
页码：813 / 814
页数：2
相关论文
共 50 条
  • [1] Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases
    Furst, DE
    [J]. LUPUS, 1996, 5 : S11 - S15
  • [2] Chloroquine and Hydroxychloroquine Toxicity
    Hickley, Nicholas M.
    Al-Maskari, Ahmed
    McKibbin, Martin
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2011, 129 (11) : 1506 - 1507
  • [3] HYDROXYCHLOROQUINE INDUCED RETINAL TOXICITY IN PATIENTS WITH RHEUMATIC DISEASES
    Maheshwari, R.
    Sankaralingam, R.
    Chinnadurai, S.
    Antony, J.
    Chilukuri, B.
    Mani, M.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 : 981 - 982
  • [4] Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates
    Tzekov, R
    [J]. DOCUMENTA OPHTHALMOLOGICA, 2005, 110 (01) : 111 - 120
  • [5] Ocular Toxicity Due to Chloroquine and Hydroxychloroquine: Electrophysiological and Visual Function Correlates
    Radouil Tzekov
    [J]. Documenta Ophthalmologica, 2005, 110 : 111 - 120
  • [6] The evolution time in rheumatic disease is associated with ocular toxicity by chloroquine
    Benavides-Brito, H
    Navarro-Cano, G
    Cavazos-Adame, H
    Garcia-Gallegos, G
    Esquivel-Valerio, JA
    Galarza-Delgado, DA
    Mohamed-Hamscho, J
    Triana-Vázquez, F
    Villarreal-Alarcón, MA
    Garza-Elizondo, MA
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 : 338 - 338
  • [7] Cardiac toxicity with chloroquine or hydroxychloroquine
    [J]. Reactions Weekly, 2018, 1706 (1) : 10 - 10
  • [8] Hydroxychloroquine ocular toxicity
    James, DG
    [J]. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 1999, 16 (02) : 227 - 227
  • [9] Hydroxychloroquine ocular toxicity
    Levy, GD
    [J]. JOURNAL OF RHEUMATOLOGY, 1998, 25 (05) : 1030 - 1031
  • [10] Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases
    dos Reis Neto, Edgard Torres
    Kakehasi, Adriana Maria
    Pinheiro, Marcelo de Medeiros
    Ferreira, Gilda Aparecida
    Lopes Marques, Claudia Diniz
    Henrique da Mota, Licia Maria
    Paiva, Eduardo dos Santos
    Salviato Pileggi, Gecilmara Cristina
    Sato, Emilia Inoue
    Monteiro Gomides Reis, Ana Paula
    Xavier, Ricardo Machado
    Provenza, Jose Roberto
    [J]. ADVANCES IN RHEUMATOLOGY, 2020, 60 (01)
12345