Hypolipidemic and antioxidant activities of Sanchi (Radix Notoginseng) in rats fed with a high fat diet

Sanchi, also known as Radix Notoginseng, is a Chinese traditional medicine prepared from roots of the herb Panax notoginseng. Sanchi is traditionally used as a hemostatic to control internal and external bleeding but also shows diverse bioactivities that include increasing coronary blood flow and reducing myocardial oxygen consumption and blood pressure. Although research into the potential cardioprotective effects of Sanchi is ongoing in the field of traditional Chinese medicine, we sought to explore potential benefits in cardiovascular disorders associated with excess cholesterol and hyperlipidemia. We have investigated the effects of Sanchi as a dietary supplement on hyperlipidemia and oxidative stress in male Sprague-Dawley rats maintained on a high-fat diet. Diets were supplemented with Sanchi at 0.25%, 0.5% and 1% (w/w) for four weeks, while control animals received no supplement. Sanchi administration to hyperlipidemic rats resulted in a significant decline in serum levels of total cholesterol, triglycerides and low density lipoprotein-cholesterol, with an increase in serum high-density lipoprotein-cholesterol levels. Treated animals also showed reduced levels of hepatic HMG-CoA reductase. Furthermore. Sanchi improved hepatic antioxidant status as assessed by superoxide dismutase and glutathione peroxidase activities and reduced levels of lipid peroxidation. These results suggest that Sanchi consumption can improve lipid profiles, inhibit peroxidation, and increase the activity of antioxidant enzymes, and is thereby likely to reduce the risk of coronary heart disease associated with hyperlipidemia and oxidative stress. (C) 2010 Elsevier GmbH. All rights reserved.