Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides

被引：2
|
作者：
Tomasi, V
Laktionov, PP
Bryksin, AV
Volod'ko, NV
Griffoni, C
Rykova, EV
Spisni, E
Kraft, R
Vlassov, VV
机构：
[1] Novosibirsk Bioorgan Chem Inst, Lab Nucl Acids Biochem, Novosibirsk 630090, Russia
[2] CNR, Inst Cytomorphol, I-40126 Bologna, Italy
[3] Max Delbruck Ctr Mol Med, Berlin, Germany
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期
关键词：
D O I：
10.1081/NCN-100002447
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.
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页码：863 / 867
页数：5
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