Male Genital Lichen Sclerosus

被引：55

作者：

Bunker, Christopher Barry ^{[1
]}

Shim, Tang Ngee ^{[1
]}

机构：

[1] Univ Coll Hosp, Dept Dermatol, 250 Euston Rd,3rd Floor,Cent Wing, London NW1 2PG, England

来源：

INDIAN JOURNAL OF DERMATOLOGY | 2015年 / 60卷 / 02期

关键词：

Male genital lichen sclerosus; etiology; pathogenesis; management; HUMAN-PAPILLOMAVIRUS INFECTION; EXTRACELLULAR-MATRIX PROTEIN-1; SQUAMOUS-CELL CARCINOMA; ET-ATROPHICUS; DERMATOLOGISTS GUIDELINES; P16(INK4A) OVEREXPRESSION; BRITISH ASSOCIATION; MALIGNANT-MELANOMA; VULVAR MELANOMA; PENILE CANCER;

D O I：

10.4103/0019-5154.152501

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS) and squamous cell carcinoma.

引用

页码：111 / 117

页数：7

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