Th17: Contributors to Allograft Rejection and a Barrier to the Induction of Transplantation Tolerance?

被引：60
|
作者：
Chadha, Radhika [1 ]
Heidt, Sebastiaan [1 ]
Jones, Nick D. [1 ]
Wood, Kathryn J. [1 ]
机构：
[1] Univ Oxford, Transplantat Res Immunol Grp, Nuffield Dept Surg Sci, Oxford, England
来源：
TRANSPLANTATION | 2011年 / 91卷 / 09期
基金：
英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
T helper cells; Regulatory T cells; Immunosuppression; Interleukin-17; REGULATORY T-CELLS; TRANSLATIONAL MINIREVIEW SERIES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; COLLAGEN-INDUCED ARTHRITIS; AUTOIMMUNE INFLAMMATION; INTERLEUKIN-17; PRODUCTION; BIOLOGICAL FUNCTIONS; LUNG TRANSPLANTS; INTERFERON-GAMMA; IL-17;
D O I：
10.1097/TP.0b013e3182126eeb
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T helper (Th) type 17 cells are a recently described CD4(+) T-cell subset that may contribute to allograft rejection and act as a barrier to the induction of transplant tolerance. This review examines the involvement of Th17 cells in transplant rejection, how immunosuppressive medication may affect their induction and maintenance and the potential plasticity of developing Th17 cells. It also addresses the complex interplay between the Th17 and regulatory T-cell developmental pathways and the susceptibility of Th17 cells to regulation. Despite accumulating evidence, the precise impact of Th17 cells on transplant rejection and the induction of tolerance require further clarification.
引用
收藏
页码：939 / 945
页数：7
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