Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

被引：87

作者：

Palenzuela, L

Hahn, NM

Nelson, RP

Arno, JN

Schobert, C

Bethel, R

Ostrowski, LA

Sharma, MR

Datta, PP

Agrawal, RK

Schwartz, JE

Hirano, M

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

[2] New York State Dept Hlth, Div Mol Med, Albany, NY USA

[3] Indiana Univ, Med Ctr, Dept Internal Med, Div Hematol & Oncol, Indianapolis, IN 46204 USA

[4] Indiana Univ, Med Ctr, Dept Internal Med, Div Infect Dis, Indianapolis, IN 46204 USA

[5] LaPorte Hosp & Hlth Serv, La Porte, IA USA

[6] N Kitsap Family Practice, Washington, DC USA

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 12期

关键词：

D O I：

10.1086/430441

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

引用

页码：E113 / E116

页数：4

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