Accumulation and depletion kinetics of erythromycin in rainbow trout (Oncorhynchus mykiss)

被引：10

作者：

Vendrell, Daniel ^{[1
]}

Serarols, Lidia ^{[2
]}

Balcazar, Jose Luis ^{[3
]}

de Blas, Ignacio ^{[1
]}

Girones, Olivia ^{[1
]}

Muzquiz, Jose Luis ^{[1
]}

Ruiz-Zarzuela, Imanol ^{[1
]}

机构：

[1] Univ Zaragoza, Lab Fish Pathol, ES-50013 Zaragoza, Spain

[2] Labs HIPRA SA, ES-17170 Girona, Spain

[3] Univ Girona, Catalan Inst Water Res, ES-17003 Girona, Spain

来源：

PREVENTIVE VETERINARY MEDICINE | 2012年 / 105卷 / 1-2期

关键词：

erythromycin; depletion; withdrawal time; rainbow trout; LACTOCOCCUS-GARVIEAE;

D O I：

10.1016/j.prevetmed.2012.02.017

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Erythromycin is an antimicrobial agent recommended for the control and treatment of diseases caused by Gram-positive bacteria. Few studies, however, have determined the metabolic and pharmacokinetic aspects of this antimicrobial agent in fish. The aim of the present study, therefore, was to determine the accumulation and depletion time of erythromycin after administration of medicated feed containing 52 mg kg(-1) body weight day(-1) for 8 days in rainbow trout (Oncorhynchus mykiss). Results were analyzed following the European Agency for Evaluation of Medicinal Products guidelines. We measured a withdrawal time of 187 degrees C-day (degrees C-day = water temperature x days), lower than the value (500 degrees C-day) recommended by Council Directive 2004/28/EC for veterinary medicinal products. Our results provide data to establish therapeutic regimens for the use of erythromycin in aquaculture. (c) 2012 Elsevier B.V. All rights reserved

引用

页码：160 / 163

页数：4

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