Amphiphilic Core-Shell Nanocomposite Particles for Enhanced Magnetic Resonance Imaging

被引:10
|
作者
Chen, Lianghui [1 ]
Niu, Dechao [1 ,2 ]
Lee, Cheng Hao [1 ]
Yao, Yuan [1 ]
Lui, Ki [1 ,3 ]
Ho, Kin Man [1 ]
Li, Pei [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
[2] East China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China
[3] Hong Kong Polytech Univ, Hong Kong Community Coll, Div Sci & Technol, Hong Kong, Hong Kong, Peoples R China
基金
中国博士后科学基金;
关键词
core-shell nanocomposites; magnetic nanoparticles; MRI contrast agents; T-2; relaxivity; IRON-OXIDE NANOPARTICLES; MRI CONTRAST AGENTS; ULTRAHIGH RELAXIVITY; FACILE SYNTHESIS; NANOCRYSTALS; DESIGN; TUMORS; SIZE;
D O I
10.1002/ppsc.201600095
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A scalable synthesis of magnetic core-shell nanocomposite particles, acting as a novel class of magnetic resonance (MR) contrast agents, has been developed. Each nanocomposite particle consists of a biocompatible chitosan shell and a poly(methyl methacrylate) (PMMA) core where multiple aggregated -Fe2O3 nanoparticles are confined within the hydrophobic core. Properties of the nanocomposite particles including their chemical structure, particle size, size distribution, and morphology, as well as crystallinity of the magnetic nanoparticles and magnetic properties were systematically characterized. Their potential application as an MR contrast agent has been evaluated. Results show that the nanocomposite particles have good stability in biological media and very low cytotoxicity in both L929 mouse fibroblasts (normal cells) and HeLa cells (cervical cancer cells). They also exhibited excellent MR imaging performance with a T-2 relaxivity of up to 364 mM(Fe)(-1) s(-1). An in vivo MR test performed on a naked mouse bearing breast tumor indicates that the nanocomposite particles can localize in both normal liver and tumor tissues. These results suggest that the magnetic core-shell nanocomposite particles are an efficient, inexpensive and safe T-2-weighted MR contrast agent for both liver and tumor MR imaging in cancer therapy.
引用
收藏
页码:756 / 763
页数:8
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