Microtubule- and Dynein-Dependent Nuclear Trafficking of Rhesus Rhadinovirus in Rhesus Fibroblasts

被引：11
|
作者：
Zhang, Wei [1 ,3 ]
Greene, Whitney [2 ]
Gao, Shou-Jiang [1 ,2 ,3 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA
[3] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
来源：
JOURNAL OF VIROLOGY | 2012年 / 86卷 / 01期
基金：
美国国家卫生研究院;
关键词：
SARCOMA-ASSOCIATED HERPESVIRUS; IMMUNODEFICIENCY-VIRUS; SIMPLEX-VIRUS; MACAQUE RHADINOVIRUS; MONKEY RHADINOVIRUS; ENDOCYTIC VESICLES; VIRAL TRANSPORT; IN-VITRO; INFECTION; CYTOSKELETON;
D O I：
10.1128/JVI.06129-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the role of microtubules in rhesus rhadinovirus (RRV) nuclear trafficking in rhesus fibroblasts. Intact microtubules and microtubule dynamics are required for RRV trafficking to perinuclear regions. RRV trafficking was reduced by an inhibitor of the dynein motor and overexpression of dynamitin. Furthermore, RRV particles are colocalized with microtubules and dynein proteins. These results highlight the important roles of microtubules and dynein-dynactin complexes in the transport of RRV particles to nuclei during primary infection.
引用
收藏
页码：599 / 604
页数：6
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