Definitive radiotherapy in elderly patients and patients with locally advanced cervical cancer with complications

Objective: To analyze the efficacy and toxicity of radiation therapy (RT) in elderly patients (>80-years-old) and patients with locally advanced cervical cancer with complications. Materials and Methods: Thirty-six patients treated with RT and 52 patients treated with concurrent chemoradiation therapy (CCRT) between 2010 and 2013 were included in this study. Treatment efficacy, treatment toxicity, overall survival, disease progression-free survival, and pelvic progression-free survival were analyzed. Results: The frequency of patients who had Grade 3-4 leukopenia in the CCRT group (57.6%) was significantly higher than that in the RT group (8.3%, p < 0.01). The complete response rates were 84% in the RT group (n = 32) and 90% in the CCRT group (n = 51) (p = 0.498). There was no statistical difference in overall survival, disease progression-free survival, and pelvic progression-free survival between the RT group and the CCRT group. Conclusion: Definitive RT in elderly and complicated cervical cancer patients was safe and effective.