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Antiretroviral Therapy as HIV Prevention: Status and Prospects

被引：67
|
作者：
Mayer, Kenneth H. [1 ,2 ,3 ]
Venkatesh, Kartik K. [2 ]
机构：
[1] Miriam Hosp, Div Infect Dis, Dept Med, Providence, RI 02906 USA
[2] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA
[3] Fenway Inst Fenway Hlth, Boston, MA USA
来源：
AMERICAN JOURNAL OF PUBLIC HEALTH | 2010年 / 100卷 / 10期
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUAL RISK BEHAVIOR; TENOFOVIR DISOPROXIL FUMARATE; NONOCCUPATIONAL POSTEXPOSURE PROPHYLAXIS; DRUG-RESISTANCE; HETEROSEXUAL TRANSMISSION; GENITAL-TRACT; SEMINAL PLASMA; PREEXPOSURE PROPHYLAXIS; REVERSE-TRANSCRIPTASE;
D O I：
10.2105/AJPH.2009.184796
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
As antiretroviral treatment of HIV infection has become increasingly accessible, attention has focused on whether these drugs can used for prevention because of increased tolerability of newer medications, decreased cost, and the limitations of other approaches. We review the status of antiretroviral HIV prevention, including chemoprophylaxis, as well as the effects of treatment of infected individuals on prevention. It is possible that the life-saving agents that have transformed the natural history of AIDS can be a critical component of HIV prevention efforts, but their ultimate role in affecting HIV transmission dynamics remains to be defined. (Am J Public Health. 2010;100:1867-1876. doi:10.2105/AJPH.2009.184796)
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页码：1867 / 1876
页数：10
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