Targeting the toll-like receptor 7 pathway in asthma: a potential immunomodulatory approach?

被引:2
|
作者
Antoniu, Sabina A. [1 ,2 ]
机构
[1] Pulm Dis Univ Hosp, Dept Med Pulm Dis 2, Iasi 700115, Romania
[2] Univ Med & Pharm Gr T Popa, Iasi, Romania
关键词
Agonist; asthma; interferon-gamma; TH2; inflammation; Toll-like receptor 7;
D O I
10.1517/14728222.2011.566561
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In allergic airways, as in asthma, inflammation and impaired functioning of toll-like receptor 7 (TLR7) has been found. The augmentation of this receptor with agonist compounds resulted in bronchodilation and a switch of the T(H)2 inflammatory pattern, specific for allergic conditions, to T(H)1 inflammation, characterised by an increased production of interferon-gamma gamma. This was a preclinical study evaluating the effects of two TLR7 agonists, imiquimod and resiquimod, on the isolated guinea pig trachea. The TLR7-related downstream signalling pathways were also assessed. Both TLR7 agonists were shown to reduce serotonin-induced bronchoconstriction, which is possibly exerted via the p38MAPK and NF-kappa kappa B pathways. Therapeutic targeting of TLR7 with specific agonists might represent a promising immunomodulatory approach in asthma, especially if systemic exposure is minimised with inhaled formulations.</.
引用
收藏
页码:667 / 669
页数:3
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