Lamotrigine in partial and generalized refractory epilepsy

Introduction. Lamotrigine (LTG) is a new antiepileptic drug that it has proved to be efficacious in treating patients with partial and generalized tonic-clonic seizures in adjunctive and monotherapy. It has similar efficacy in comparison with carbamazepine and phenytoin with a minor number of adverse experiences. Patients and methods. We report the use of LTG in adjunctive therapy in 106 adults patients with refractory epilepsy (efficacy and safety) with partial and generalized seizures, with follow-up to 3.4 seizures. The LTG mean closes used was 273 mg/day Results. 66% of patients experienced a greater than or equal to 50% reduction in seizure frequency, with 30% in remission. Both partial, secondarily generalized and generalized seizures showed significant reductions with LTG treatment. LTG was well tolerated in our patients. Side effects were minor. No case of rash was seen. Conclusion. LTG is a excellent agent for adjunctive therapy in refractory epilepsy.