Gut microbiome: Microflora association with obesity and obesity-related comorbidities

被引：19

作者：

Lone, Jameel Barkat ^{[1
]}

Koh, Wee Yin ^{[2
]}

Parray, Hilal A. ^{[1
]}

Paek, Woon K. ^{[3
]}

Lim, Jeongheui ^{[3
]}

Rather, Irfan A. ^{[4
]}

Jan, Arif Tasleem ^{[5
]}

机构：

[1] Daegu Univ, Dept Biotechnol, Gyongsan, Gyeongbuk, South Korea

[2] Univ Sains Malaysia, Sch Ind Technol, Food Technol Div, Minden, Penang, Malaysia

[3] Minist Sci ICT & Future Planning, Natl Sci Museum, Daejeon, South Korea

[4] Yeungnarn Univ, Sch Biotechnol, Dept Appl Microbiol & Biotechnol, Gyongsan, Gyeongbuk, South Korea

[5] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Rajouri, India

来源：

MICROBIAL PATHOGENESIS | 2018年 / 124卷

关键词：

Gut microbiota; Lifestyle; Metabolic disorders; Obesity; Metabolic endotoxemia; DIET-INDUCED OBESITY; INTESTINAL MICROBIOTA; METABOLIC SYNDROME; MECHANISMS; FAT; IMPACT; MODULATION; METAGENOME; CAPACITY; BACTERIA;

D O I：

10.1016/j.micpath.2018.08.036

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Obesity and obesity-related comorbidities have transformed into a global epidemic. The number of people suffering from obesity has increased dramatically within the past few decades. This rise in obesity cannot alone be explained by genetic factors; however, diet, environment, lifestyle, and presence of other diseases undoubtedly contribute towards obesity etiology. Nevertheless, evidence suggests that alterations in the gut microbial diversity and composition have a role to play in energy assimilation, storage, and expenditure. In this review, the impact of gut microbiota composition on metabolic functionalities, and potential therapeutics such as gut microbial modulation to manage obesity and its associated comorbidities are highlighted. Optimistically, an understanding of the gut microbiome could facilitate the innovative clinical strategies to restore the normal gut flora and improve lifestyle-related diseases in the future.

引用

页码：266 / 271

页数：6

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