Motion frozen 18F-FDG cardiac PET

PET reconstruction incorporating spatially variant 3D Point Spread Function (PSF) improves contrast and image resolution. "Cardiac Motion Frozen" (CMF) processing eliminates the influence of cardiac motion in static summed images. We have evaluated the combined use of CMF- and PSF-based reconstruction for high-resolution cardiac PET. Static and 16-bin ECG-gated images of 20 patients referred for F-18-FDG myocardial viability scans were obtained on a Siemens Biograph-64. CMF was applied to the gated images reconstructed with PSF. Myocardium to blood contrast, maximum left ventricle (LV) counts to defect contrast, contrast-to-noise (CNR) and wall thickness with standard reconstruction (2D-AWOSEM), PSF, ED-gated PSF, and CMF-PSF were compared. The measured wall thickness was 18.9 +/- A 5.2 mm for 2D-AWOSEM, 16.6 +/- A 4.5 mm for PSF, and 13.8 +/- A 3.9 mm for CMF-PSF reconstructed images (all P < .05). The CMF-PSF myocardium to blood and maximum LV counts to defect contrasts (5.7 +/- A 2.7, 10.0 +/- A 5.7) were higher than for 2D-AWOSEM (3.5 +/- A 1.4, 6.5 +/- A 3.1) and for PSF (3.9 +/- A 1.7, 7.7 +/- A 3.7) (CMF vs all other, P < .05). The CNR for CMF-PSF (26.3 +/- A 17.5) was comparable to PSF (29.1 +/- A 18.3), but higher than for ED-gated dataset (13.7 +/- A 8.8, P < .05). Combined CMF-PSF reconstruction increased myocardium to blood contrast, maximum LV counts to defect contrast and maintained equivalent noise when compared to static summed 2D-AWOSEM and PSF reconstruction.