Ni-Catalyzed Highly Chemo-, Regio-, and Enantioselective Decarboxylative Aldol Reaction of β,γ-Unsaturated α-Ketoesters with β-Ketoacids

被引：40
|
作者：
Wei, Ai-Jia [1 ]
Nie, Jing [1 ]
Zheng, Yan [1 ]
Ma, Jun-An [1 ]
机构：
[1] Tianjin Univ, Key Lab Syst Bioengn, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Dept Chem,Minist Educ, Tianjin 300072, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 08期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC ALDOL; MANNICH REACTION; KETO ACIDS; 3-HYDROXY OXINDOLES; MICHAEL ADDITION; ESTERS; CONSTRUCTION; BIOSYNTHESIS; CONVENIENT; ALKALOIDS;
D O I：
10.1021/jo502741z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel Ni-catalyzed decarboxylative aldol reaction of beta,gamma-unsaturated alpha-ketoesters with beta-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a Convenient approach to access enantioenriched chiral tertiary alcohols.
引用
收藏
页码：3766 / 3776
页数：11
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