Dengue virus in the brain of a fatal case of hemorrhagic dengue fever

被引：114
|
作者：
Ramos, C
Sánchez, G
Pando, RH
Baquera, J
Hernández, D
Mota, J
Ramos, J
Flores, A
Llausás, E
机构：
[1] Inst Nacl Salud Publ, Ctr Invest Enfermedades Infecc, Dept Arbovirus, Cuernavaca 62508, Morelos, Mexico
[2] Inst Nal Nutr, Dept Patol, Mexico City, DF, Mexico
[3] Univ Autonoma Sinaloa, Fac Med, Culiacan, Sinaloa, Mexico
[4] Hosp Pediat Sinaloa, Dept Infectol, Culiacan, Sinaloa, Mexico
来源：
JOURNAL OF NEUROVIROLOGY | 1998年 / 4卷 / 04期
关键词：
dengue virus; human brain; hemorrhagic fever;
D O I：
10.3109/13550289809114548
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurologic complications associated with dengue fever are in general unusual. However, recent reports evidence more frequent neurologic alterations. In Mexico, neurologic involvement has not been reported in dengue cases. This report demonstrates the detection of dengue virus in the brain of a fatal case of dengue hemorrhagic fever. Serotype 4 was detected by immunohistochemistry and by RT-PCR in the inferior olivary nucleus of medulla and in the granular layer of cerebellum. Immunoreactivity was observed in neurons, astrocytes, microglia and endothelial cells. Our results emphasize the importance of neurologic manifestations in patients with dengue fever.
引用
收藏
页码：465 / 468
页数：4
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