Coronary artery disease is associated with higher epicardial Retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue

被引：46

作者：

Salgado-Somoza, Antonio ^{[1
]}

Teijeira-Fernandez, Elvis ^{[2
]}

Rubio, Jose ^{[3
]}

Couso, Elena ^{[4
]}

Gonzalez-Juanatey, Jose R. ^{[1
,2
]}

Eiras, Sonia ^{[1
]}

机构：

[1] Univ Clin Hosp, Cardiovasc Div, Sanit Res Inst, Santiago De Compostela, Spain

[2] Univ Clin Hosp, Dept Cardiol & Med, Coronary Unit, Santiago De Compostela, Spain

[3] Univ Clin Hosp, Dept Heart Surg, Santiago De Compostela, Spain

[4] Univ Clin Hosp, Dept Pathol, Santiago De Compostela, Spain

来源：

CLINICAL ENDOCRINOLOGY | 2012年 / 76卷 / 01期

关键词：

CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; VISCERAL ADIPOSITY; SERUM RETINOL-BINDING-PROTEIN-4; METABOLIC SYNDROME; EXPRESSION; OBESITY; HYPERTENSION; INFLAMMATION; FAT;

D O I：

10.1111/j.1365-2265.2011.04140.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD). Recently, several studies have shown that epicardial adipose tissue (EAT) differs from subcutaneous adipose tissue (SAT) and plays a role on the physiopathology of CAD because of its proximity to the coronary arteries. We aimed to study the expression and secretion levels of RBP4 in both fat tissues and explore its possible association with CAD.

引用

页码：51 / 58

页数：8

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