Antifertility Compound from the Seeds of Carica papaya

被引：12
|
作者：
Julaeha, Euis [1 ]
Permatasari, Yunita [1 ]
Mayanti, Tri [1 ]
Diantini, Ajeng [2 ]
机构：
[1] Padjadjaran State Univ, Fac Math & Nat Sci, Dept Chem, Jl Raya Bandung Sumedang Km 21, Jatinangor 45643, Sumedang, Indonesia
[2] Padjadjaran State Univ, Fac Pharm, Jatinangor 45643, Sumedang, Indonesia
来源：
3RD INTERNATIONAL SEMINAR ON CHEMISTRY 2014 | 2015年 / 17卷
关键词：
antifertility; Carica papaya; Rattus norvegicus; 1,2,3,4-tetrahydropyridin-3-yl-octanoate;
D O I：
10.1016/j.proche.2015.12.135
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The antifertility effects of the isolated compound from the seeds of Carica papaya were investigated. The aim of this research is to obtain the chemical structure of antifertility compound againts spermatozoa of the white rat (Rattus novergicus) from the seeds of C. papaya. The ethyl acetate extract (7 g) was separated by solvent partition and a combination of column chromatography to yield a colorless solid isolated (26.1 mg). The chemical stucture of isolated compound was elucidated on the basis of spectroscopic evidences and identified as a 1,2,3,4-tetrahydropyridin-3-yl-octanoate. The isolated compound showed the significant difference of activity of compound compared with the control and decreased motility and viability and increased abnormality of the spermatozoa with 32%, 18% and 294%, respectively.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 50 条
  • [1] ANTIFERTILITY EFFECTS OF AQUEOUS EXTRACT OF CARICA-PAPAYA SEEDS IN MALE-RATS
    LOHIYA, NK
    GOYAL, RB
    JAYAPRAKASH, D
    ANSARI, AS
    SHARMA, S
    [J]. PLANTA MEDICA, 1994, 60 (05) : 400 - 404
  • [2] Studies on antifertility effect of pawpaw seeds (Carica papaya) on the gonads of male albino rats
    Udoh, P
    Kehinde, A
    [J]. PHYTOTHERAPY RESEARCH, 1999, 13 (03) : 226 - 228
  • [3] CYSTEINE PROTEINASE-INHIBITOR FROM PAPAYA (CARICA-PAPAYA L) SEEDS
    MOSOLOV, VV
    ZYMATCHEVA, AV
    IEVLEVA, EV
    [J]. BIOCHEMIE UND PHYSIOLOGIE DER PFLANZEN, 1991, 187 (03): : 237 - 242
  • [4] Characterization of a high oleic oil extracted from papaya (Carica papaya L.) seeds
    Malacrida, Cassia Roberta
    Kimura, Mieko
    Jorge, Neuza
    [J]. CIENCIA E TECNOLOGIA DE ALIMENTOS, 2011, 31 (04): : 929 - 934
  • [5] In vitro and in vivo germination of papaya (Carica papaya L.) seeds
    Bhattacharya, J
    Khuspe, SS
    [J]. SCIENTIA HORTICULTURAE, 2001, 91 (1-2) : 39 - 49
  • [6] Effects of Chloroformic Extracts from Washed and Unwashed Papaya Seeds (Carica papaya) on the Sperm Concentration of Dogs
    Ortega-Pacheco, A.
    Jimenez-Coello, M.
    Gutierrez-Blanco, E.
    Acosta-Viana, K. Y.
    Guzman-Marin, E.
    Zavala-Sanchez, M. A.
    Montalvo-Beltran, N. E.
    Perez-Gutierrez, M. S.
    [J]. REPRODUCTION IN DOMESTIC ANIMALS, 2010, 45 (06) : 1126 - 1129
  • [7] Effect of high hydrostatic pressure on seeds Carica papaya
    Alan Costa Sarcinelli Santos
    Antônio Alberto Ribeiro Fernandes
    Patrícia Machado Ribeiro Fernandes
    [J]. BMC Proceedings, 8 (Suppl 4)
  • [8] SOME STUDIES ON THE PROTEINS OF CARICA-PAPAYA SEEDS
    MARFO, EK
    OKE, OL
    AFOLABI, OA
    [J]. FOOD CHEMISTRY, 1986, 22 (04) : 267 - 277
  • [9] Activity of papaya seeds (Carica papaya) against Meloidogyne incognita as a soil biofumigant
    Vanessa Alves Gomes
    Vicente P. Campos
    Julio Carlos Pereira da Silva
    Fabíola de Jesus Silva
    Marcela de Freitas Silva
    Marcio Pozzobon Pedroso
    [J]. Journal of Pest Science, 2020, 93 : 783 - 792
  • [10] Activity of papaya seeds (Carica papaya) against Meloidogyne incognita as a soil biofumigant
    Gomes, Vanessa Alves
    Campos, Vicente P.
    Pereira da Silva, Julio Carlos
    Silva, Fabiola de Jesus
    Silva, Marcela de Freitas
    Pedroso, Marcio Pozzobon
    [J]. JOURNAL OF PEST SCIENCE, 2020, 93 (02) : 783 - 792
12345