Do dried blood spots (DBS) have the potential to support result management processes in routine sports drug testing?

被引：33
|
作者：
Thevis, Mario [1 ,2 ]
Kuuranne, Tiia [3 ,4 ,5 ,6 ]
Dib, Josef [1 ]
Thomas, Andreas [1 ]
Geyer, Hans [1 ,2 ]
机构：
[1] German Sport Univ Cologne, Inst Biochem, Ctr Prevent Doping Res, Sportpk Mungersdorf 6, D-50933 Cologne, Germany
[2] European Monitoring Ctr Emerging Doping Agents, Cologne, Germany
[3] Univ Ctr Legal Med, Swiss Lab Doping Anal, Geneva, Switzerland
[4] Univ Ctr Legal Med, Swiss Lab Doping Anal, Lausanne, Switzerland
[5] CHU Vaudois, Epalinges, Switzerland
[6] Univ Lausanne, Epalinges, Switzerland
来源：
DRUG TESTING AND ANALYSIS | 2020年 / 12卷 / 06期
关键词：
alternative matrices; doping; mass spectrometry; sport; WHOLE-BLOOD; HUMAN URINE; METABOLITES; PHARMACOKINETICS; IDENTIFICATION; PLASMA;
D O I：
10.1002/dta.2790
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Dried blood spots (DBS) have been considered as complementary matrix in sports drug testing for many years. Especially concerning substances prohibited in-competition only, the added value of DBS collected concomitantly with routine doping control urine samples has been debated, and an increasing potential of DBS has been discussed in the scientific literature. To which extent and under which prerequisites DBS can contribute to enhanced anti-doping efforts is currently evaluated. As a proof-of-principle, two analytical applications, one targeting cocaine/benzoyl ecgonine and the other prednisone/prednisolone, are presented in this perspective to indicate potential added value but also presently existing limitations of the DBS approach.
引用
收藏
页码：704 / 710
页数：7
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