Recent development in the field of dual COX/5-LOX inhibitors

被引：28

作者：

Julémont, F ^{[1
]}

Dogné, JM ^{[1
]}

Pirotte, B ^{[1
]}

de Leval, X ^{[1
]}

机构：

[1] Univ Liege, Dept Med Chem, Nat & Synth Drugs Res Ctr, B-4000 Liege, Belgium

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 06期

关键词：

cancer; cyclooxygenases; dual inhibitors; inflammation; leukotrienes;

D O I：

10.2174/1389557043403747

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclooxygenases and lipoxygenase are key enzymes in the arachidonic acid metabolism. Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. Compared to COX or LOX pathways single inhibitors, dual inhibitors present at least two major advantages. First, dual inhibitors, by acting on the two major arachidonic acid metabolic pathways, possess a wide range of anti-inflammatory activities. Secondly, dual inhibitors appear to be almost exempt from gastric toxicity, which is the most troublesome side effect of non-selective COX inhibitors.

引用

页码：633 / 638

页数：6

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