Mitochondrial dysfunction in metabolic and cardiovascular diseases associated with cardiolipin remodeling

被引:31
|
作者
El-Hafidi, Mohammed [1 ]
Correa, Francisco [1 ]
Zazueta, Cecilia [1 ]
机构
[1] Inst Nacl Cardiol, Dept Biomed Cardiovasc, 1 Ch, Ciudad De Mexico 14080, Mexico
关键词
Cardiolipin; Mitochondrial function; Metabolic diseases; ACYL-CHAIN COMPOSITION; INDEPENDENT PHOSPHOLIPASE A(2); CYTOCHROME-C RELEASE; DIET-INDUCED OBESITY; BARTH-SYNDROME; TETRALINOLEOYL-CARDIOLIPIN; SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; LINOLEIC-ACID;
D O I
10.1016/j.bbadis.2020.165744
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardiolipin (CL) is an acidic phospholipid almost exclusively found in the inner mitochondrial membrane, that not only stabilizes the structure and function of individual components of the mitochondrial electron transport chain, but regulates relevant mitochondrial processes, like mitochondrial dynamics and cristae structure maintenance among others. Alterations in CL due to peroxidation, correlates with loss of such mitochondrial activities and disease progression. In this review it is recapitulated the current state of knowledge of the role of cardiolipin remodeling associated with mitochondrial dysfunction in metabolic and cardiovascular diseases.
引用
收藏
页数:11
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