Prescribing direct-acting oral anticoagulants - Mind the evidence gap

被引：1

作者：

Adeyeye, Elizabeth ^{[1
]}

Maniero, Carmela ^{[2
]}

Magavern, Emma F. ^{[2
]}

Ferner, Robin E. ^{[3
,4
]}

McGettigan, Patricia ^{[2
]}

机构：

[1] Barts Hlth NHS Trust, Dept Clin Pharmacol, Cardiovasc Med, London, England

[2] Queen Mary Univ London, Fac Med & Dent, William Harvey Res Inst, London, England

[3] City Hosp, West Midlands Ctr Adverse Drug React, Birmingham, W Midlands, England

[4] Univ Birmingham, Sch Clin & Expt Med, Birmingham, W Midlands, England

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2022年 / 88卷 / 11期

关键词：

anticoagulants; cardiovascular pharmacology; drug information; drug regulation; medication safety; ATRIAL-FIBRILLATION OBSERVATIONS; OBESE-PATIENTS; BODY-WEIGHT; WARFARIN; RIVAROXABAN; APIXABAN; STROKE; DABIGATRAN; EFFICACY; SAFETY;

D O I：

10.1111/bcp.15450

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Direct-acting oral anticoagulants (DOACs) are licensed for the prevention of thromboembolism in non-valvular atrial fibrillation, amongst other indications. Prescribers use information derived from the summary of product characteristics which is based on the key trials supporting the DOAC's market authorisation. However, prescribers may not be aware of the limitations within these trials regarding underrepresentation of patient populations commonly encountered in clinical practice and how this may adversely impact them. This review highlights the gaps in the licensing evidence using four clinical vignettes that explore prescribing challenges in older adults, female patients, patients with obesity and patients from non-Europid ethnic backgrounds.

引用

页码：4724 / 4731

页数：8

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