Synthesis of novel Schiff bases and evaluation of their antimicrobial activities

被引：0
|
作者：
Huq, C. A. M. A. [1 ]
Fouzia, S. [1 ]
机构：
[1] Univ Madras, New Coll, Post Grad & Res Dept Chem, Madras 600014, Tamil Nadu, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2015年 / 54卷 / 04期
关键词：
Dihydropyrimidinone; Schiff base; hydrazinecarbothioamide; 1,3,4-thiadiazol-2-amine; antibacterial activity; antifungal activity; RESISTANCE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An easy route for the synthesis of Schiff bases containing dihydropyrimidinone moiety has been reported for the first time. The dihydropyrimidinones on treatment with thiosemicarbazide result in the formation of the corresponding hydrazinecarbothioamide. Dehydrated annulation of hydrazinecarbothioamide with concentrated sulphuric acid, followed by ammonia yield the corresponding 1,3,4-thiadiazol-2-amine, which on condensation with various selected aromatic aldehydes furnish the Schiff bases 4a-f. The antimicrobial studies of the novel Schiff bases have been carried out on different microbes.
引用
收藏
页码：551 / 555
页数：5
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