Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen

被引：0
|
作者：
Mirjana, D
Olgica, L
Stanislava, S
Jelena, R
机构：
[1] Immunol Res Ctr, YU-11221 Belgrade, Yugoslavia
[2] Max Planck Inst Expt Med, D-35075 Gottingen, Germany
来源：
ACTA VETERINARIA-BEOGRAD | 2000年 / 50卷 / 5-6期
关键词：
experimental allergic encephalomyelitis; DA rats; anti-myelin basic protein antibodies;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week-old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
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页码：289 / 296
页数：8
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