Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production

被引：39
|
作者：
Song, Dan [1 ,2 ]
Zhao, Min [1 ,2 ]
Feng, Liuxiang [3 ]
Wang, Pingyi [2 ]
Li, Yimei [2 ]
Li, Wenhua [1 ,2 ]
机构：
[1] Xizang Minzu Univ, Sch Med, Engn Res Ctr Tibetan Med Detect Technol, Minist Educ, Xianyang 712082, Shaanxi, Peoples R China
[2] Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China
[3] Peoples Hosp Yulong Naxi Autonomous Cty Lijiang C, Yulong Naxi Autonomous C 674100, Yunnan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 142卷
关键词：
Salidroside; Acute lung injury; LPS; TNF alpha; IL-6; MODELS;
D O I：
10.1016/j.biopha.2021.111949
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Acute lung injury is a fatal condition characterized by excessive inflammation responses. Salidroside, the active constituent of Rhodiola rosea, possesses properties including anti-oxidation, anti-aging, anti-inflammatory, anti-hypoxia, and anti-cancer activities. In the present study, Salidmside attenuated acute lung injury via inhibition of inflammatory cytokine production. Rats pre-treated with Salidroside showed attenuated lipopolysaccharide (LPS)-induced pathological damage and suppressed tumor necrosis factor-alpha (TNF alpha) and interleukin 6 (IL-6) secretion in the lung. Furthermore, flow cytometry showed that Salidroside reduced the production of TNF alpha and IL-6 in NR8383 alveolar macrophages. These findings suggest that Salidroside may attenuate LPS-induced acute lung injury.
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页数：7
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