Recent progress on the discovery of antiamoebic agents

被引：13

作者：

Hayat, Faisal ^{[1
]}

Azam, Amir ^{[2
]}

Shin, Dongyun ^{[1
]}

机构：

[1] Gachon Univ, Coll Pharm, 191 Hambakmoe Ro, Inchon 21936, South Korea

[2] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

Antiamoebic; Entamoeba histolytica; Amoebiasis; Inhibitor; Protozoan; ENTAMOEBA-HISTOLYTICA INFECTION; BIOLOGICAL EVALUATION; INVASIVE AMEBIASIS; ANTIPROTOZOAL ACTIVITY; CRYSTAL-STRUCTURE; IN-VITRO; METRONIDAZOLE; DERIVATIVES; MEN; SEX;

D O I：

10.1016/j.bmcl.2016.09.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A large number of protozoans infect humans but Entamoeba histolytica is the only organism responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle-based antiamoebic agents have been previously synthesized as E. histolytica inhibitors and while some of these agents have shown moderate activity, the search for a novel and ideal antiamoebic compound is still ongoing. In this digest Letter, we present the latest data on antiamoebic agents from 2011 to 2016 based on the different classes of heterocyclic agents. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5149 / 5159

页数：11

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